AustralieFrV1, Main, Exploration, bibRecord, 000179

The role of androgen receptors in atherosclerosis.

Identifieur interne : 000179 ( Main/Exploration ); précédent : 000178; suivant : 000180

The role of androgen receptors in atherosclerosis.

Auteurs : Kaloyan Takov [Royaume-Uni] ; Junxi Wu [Royaume-Uni] ; Martin A. Denvir [Royaume-Uni] ; Lee B. Smith [Australie] ; Patrick W F. Hadoke [Royaume-Uni]

Source :

Molecular and cellular endocrinology [ 1872-8057 ] ; 2017.

RBID : pubmed:29024781

Abstract

Male disadvantage in cardiovascular health is well recognised. However, the influence of androgens on atherosclerosis, one of the major causes of many life-threatening cardiovascular events, is not well understood. With the dramatic increase in clinical prescription of testosterone in the past decade, concerns about the cardiovascular side-effects of androgen supplementation or androgen deprivation therapy are increasing. Potential atheroprotective effects of testosterone could be secondary to (aromatase-mediated) conversion into oestradiol or, alternatively, to direct activation of androgen receptors (AR). Recent development of animal models with cell-specific AR knockout has indicated a complex role for androgen action in atherosclerosis. Most studies suggest androgens are atheroprotective but the precise role of AR remains unclear. Increased use of AR knockout models should clarify the role of AR in atherogenesis and, thus, lead to exploitation of this pathway as a therapeutic target.

DOI: 10.1016/j.mce.2017.10.006
PubMed: 29024781

Affiliations:

Le document en format XML

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Serveur d'exploration sur les relations entre la France et l'Australie

The role of androgen receptors in atherosclerosis.

The role of androgen receptors in atherosclerosis.

Source :

Abstract

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	Serveur d'exploration sur les relations entre la France et l'Australie
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